Cindy's Answer
Chasing and biting at fast-moving and screaming kids is many dogs' prey-driven behavior. When dogs aren't exposed to these triggers as pups/young dogs it can take you by surprise.
This is the same reason dogs chase blowing leaves, squirrels, cars, bikes, and joggers.
I'd start with basic obedience and come when called because the material covered in those courses is the foundation of everything we expect from our dogs. I've added links to the courses below.
In the meantime, when you have the grandkids around keep her on a leash so you can prevent her from rehearsing this behavior (or use a baby gate or crate to keep her from having access to the kids when they're running around) We do also have a course on managing dogs in the home. We have a multi-dog home so we employ a lot of strategies for living with our dogs until they are fully trained. Otherwise dogs can practice problematic behaviors, and all behaviors become stronger when rehearsed (both good and bad)
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