There are a couple of other threads going on right now about the pre-NSAID bloodwork and the side effects to be watching for.
http://leerburg.com/webboard/thread.php?topic_id=31987&page=1
Scroll down to my post that starts with
"There's no way I'd still be doing that vax on a ten-year-old dog" (4th post down):
QUOTE: "Dogs are much more vulnerable to NSAID side effects like ulcers and kidney and liver damage than humans are (and this includes aspirin). No NSAID protocol should be commenced without blood work. I imagine the vet was relying on the November bloodwork for his baseline?
BTW, Deramaxx is one of the two NSAIDs I personally would choose first for any dog of mine who needed an NSAID to provide quality of life. In fact, I have a senior on daily Deramaxx (deracoxib). That doesn't mean that it's any less crucial to do pre-protocol bloodwork (and regular re-testing during the protocol) or that the side effects suggesting GI distress can be ignored. The most common side effects of NSAIDs in dogs are nausea, vomiting or diarrhea, and inappetence. "
Also, if you search using NSAID for your search term (upper right, "advanced search," and expand your time to a couple of years) you'll find that your vet should have carefully explained what to watch for and why." END QUOTE
Or here is the FDA warning from
http://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm055434.htm ....
Veterinary Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used to control pain and inflammation. Inflammation - the body’s response to irritation or injury - is characterized by redness, warmth, swelling, and pain. NSAIDs work by blocking the production of prostaglandins, the body chemicals that cause inflammation.
In companion animal medicine, approved veterinary NSAIDs are used to control the pain and inflammation associated with osteoarthritis in dogs and horses. Some veterinary NSAIDs are also approved for the control of postoperative pain in dogs and cats. There are potential risks associated with the use of NSAIDs. Veterinarians and pet owners should be aware of the following facts:
All dogs and cats should undergo a thorough history and physical examination before beginning NSAID therapy.
Appropriate blood/urine tests should be performed to establish baseline data prior to, and periodically during, administration of any NSAID.
Common side effects include vomiting, diarrhea, not eating/eating less, and lethargy. If your pet experiences any of these potential side effects, STOP administering the medication and contact your veterinarian immediately.
Veterinary NSAIDS may be associated with gastrointestinal ulcers/perforations, liver, and kidney toxicity.
Serious side effects associated with the use of NSAIDs can occur with or without warning and, in some cases, result in death.
Use with other anti-inflammatory drugs, such as other NSAIDs and corticosteroids, should be avoided.
Patients at greatest risk for kidney problems are those that are dehydrated, are on diuretic treatment, or have pre-existing kidney, heart, and/or liver problems.
NSAIDs can cause stomach or intestinal bleeding.
Risks associated with NSAIDs are detailed on the package inserts and Client Information Sheets that accompany all veterinary NSAIDS dispensed to clients. A Client Information Sheet should always be given to the client with each NSAID prescription. Pet owners should read this information carefully. Owners and veterinarians should carefully consider the potential benefits and risks of using an NSAID and other treatment options before deciding to use an NSAID. END
All of this should have been carefully gone over with you by your vet.
This in no way implies that NSAIDs aren't often magic bullets, because they very often are. There are many dogs who would have had to be put down long ago but who have quality of life because of an NSAID. However, it does tell you how remiss it is of any vet not to have followed these guidelines.
I have an HD/OA senior on Deramaxx, and his continued life and comfort are a direct result of it, but each of those safety steps were (and still are) followed.