Well, my POV comes partly from canine nutritional anthropology, or history.
There was a time when we (and the dogs) naturally had a diet that would yield about a 1-to-1 ratio of Omega 6s and Omega 3s.
Omega 6s are fats that promote an inflammatory response. This is necessary, of course, as a primary mechanism for sending healing blood to a wound. Omega 3s promote an inflammation-suppression response, which also is a primary mechanism for reining in inflammation that has run amok or that is not serving a healing benefit.
That is very oversimplified; the point I take from this is that we (and our dogs) evolved eating a pretty balanced 6-to-3 diet.
Now we eat a diet that's superabundant in 6s. Poultry and red meat that's fed grain instead of pasture and poultry-yard bugs, etc., no longer store the Omega 3s in their fat and tissue that they did. All the soy and corn and other oils that are most commonly used in processed foods are also heavy in Omega 6s.
Mediterranean (people) diets have two-to-one ratios of omega-6 to omega-3 fatty acids, I have read in research of Omega 3s. In the United States, the ratio of omega-6 to omega-3 fatty acids in diets is more like 20 to 1.
PositiveDogs.com says: Suggested dose is 1000 mg (with 180 mg EPA and 120 mg DHA) per ten pounds of body weight. END
Shawn Messonier (The Allergy Solution for Dogs, sold here and very good, IMO) and other DVMs I have read recommend at least a 5-to-1 ratio.
He says:
While many veterinarians, including me, use fatty acids for a variety of medical problems, there is considerable debate about their use. One part of the debate concerns the dosage to use. Due to their anti-inflammatory effects, I routinely use large doses of fatty acids when treating atopic dermatitis in pets. Like most doctors, I recommend 2 to 4 times the label dose, as research in allergy treatment indicates that the label dose on most products is too low to exert an anti-inflammatory influence.
In people, research suggests that the effective dosage is from 1.4 to 2.8 grams of GLA per day, or 1.7 grams of EPA and 0.9 grams of DHA per day. It's hard for people to take that much using the supplements currently available because they come in a much lower dose. If this dosage is correct, translating this dosage to dogs (adjusting for weight) means a 50-pound dog would need to take 10 or more fatty acids capsules per day, depending upon the supplement. END
He is discussing a combo 6 and 3 supplement there.
http://www.peteducation.com/article.cfm?cls=2&cat=1662&articleid=666
says: Previously, it was thought that the ratio should be approximately 15:1. Current recommendations are for ratios of 10:1 to 5:1. END
http://www.judyshealthcafe.com/fishoil.htm
says: Though some pet diets may include Omega-3 fatty acids, virtually none include satisfactory amounts of the most important Omega-3 fatty acids EPA and DHA. Many pet foods contain primarily Omega-6 fatty acids from vegetable oils resulting in a highly unbalanced ratio of Omega-6s to Omega-3s. END
This site uses the 1000 mg per ten pounds ratio:
http://www.b-naturals.com/Feb2005.php
Lew Olson says: I would start with 1,000 mg of the salmon or fish oil, at one per 20 lbs of body weight daily, then increase to 1,000 mg per ten pounds of body weight after a week or so. End He adds that mackerel, etc., would be beneficial IN ADDITION TO the oil. (His capitals.)
Dr. Messonier also says:
Fish oil supplementation is very safe. The most common side effect seen in people and pets is a fish odor to the breath or the skin. Because fish oil has a mild "blood-thinning" effect, it should not be combined with powerful blood-thinning medications, such as Coumadin (warfarin) or heparin, except on a veterinarian's advice. END
TheWholeDog.org says:
The lack of Omega 3 and the excessive amount of Omega 6 in the modern diet ultimately create degenerative conditions. The store-bought processed foods still do not supply an adequate amount of Omega 3 to properly balance the ratio. Many nutritional supplements are still promoting and loading up the Omega 6 (LA) fatty acids -exacerbating an already severely imbalanced and unhealthy situation. The best solution to insure our pet's health is to provide a high quality Omega 3 Fish oil supplement along with a premium diet. END
The Grizzly instructions for use work out to about 1000 mg per ten pounds.
BUT I have read other sources that recommend 1000 mg per twenty pounds.
So .... I don't know if this helps. I hesitate to say "Ask your vet" because I find that very few vets have much nutrition background. How about "Ask a vet with a nutrition specialty" ...
I am NOT a health professional. There are researchers and vets who back up the 1-gram-per-10-pounds dose, and I've had what I think are very good results with it, but in the end, it's really JMO.