 Ivermectin in Heartguard and GSDs
#195147 - 05/16/2008 08:42 AM |
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My dogs are on Heartguard only during certain months of the year. However, while I was researching something unrelated, I stumbled across some warnings about Ivermectin and GSDs.
I know that Collies and certain other breeds are not to be given Ivermectin ("white feet do not treat"), but after further research saw that GSDs were listed as well.
I've read that Interceptor is a better choice for dogs with potential sensitivity.
Anyone heard anything about the Ivermectin in Heartguard being an issue with GSDs or is this not something to be worried about? And since he and the Corgi have been on it before with no obvious issues does that mean that it's nothing to worry about with my specific dogs?
Also, I've been giving Frontline and Heartguard at different times of the month just to be overly cautious--but does anyone know if there is any reason why they can't be given at the same time?
Carbon |
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Re: Ivermectin in Heartguard and GSDs
[Re: Amber Morgan ]
#195150 - 05/16/2008 09:04 AM |
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My dog didn't tolerate Heartguard at all -- she would immediately throw it up within minutes.
No problem whatsoever after switching to Interceptor.
Interesting to know that there is a sensitivity amoung GSD's -- does the information you found list any symptoms to watch for?
My indicator was pretty clear -- she just couldn't keep it down!
Katie
SG S'Eliana vom Kraftwerk IPO3,AD,CGC,KKL1
Jaya von der Olgameister AD, CGC
Pierre, the Poodle! |
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Re: Ivermectin in Heartguard and GSDs
[Re: Katie O'Connor ]
#195152 - 05/16/2008 09:32 AM |
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I found a few sites and didn't bookmark them. I'll try to find the rest of them but from http://www.vetmed.wsu.edu/depts-VCPL/:
It is well known that Collies and related breeds can have adverse reactions to drugs such as ivermectin, loperamide (Imodium®  , and others. It was previously unknown why some individual dogs were sensitive and others were not. Advances in molecular biology at the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine have led to the discovery of the cause of multi-drug sensitivity in affected dogs. The problem is due to a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay--or even death. Approximately 3 of every 4 Collies in the United States have the mutant MDR1 gene. The frequency is about the same in France and Australia, so it is likely that most Collies worldwide have the mutation. The MDR1 mutation has also been found in Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds , Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.
Symptoms of toxicity are listed on Heartguard's website, about halfway down:
http://www.petshed.com/petcyclopedia/all-about-heartgard-for-dogs.html
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Re: Ivermectin in Heartguard and GSDs
[Re: Amber Morgan ]
#195154 - 05/16/2008 09:48 AM |
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Allergic reactions to the drug base (beef in the chewable formulation) are more common than reactions to the toxicity of the drug itself
From: http://www.petshed.com/petcyclopedia/all-about-heartgard-for-dogs.html
I bet the vomiting in my dog's instance was a reaction to the drug base as mentioned above. It doesn't seem like it was in her stomach long enough to be a symptom of toxicity to the Ivermectin.
Interesting biology research behind it!
Katie
SG S'Eliana vom Kraftwerk IPO3,AD,CGC,KKL1
Jaya von der Olgameister AD, CGC
Pierre, the Poodle! |
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Re: Ivermectin in Heartguard and GSDs
[Re: Katie O'Connor ]
#195157 - 05/16/2008 10:07 AM |
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this is question about heart worm meds, i we to the vet not to long ago and told her i dont give heart worm meds year round, she suggested i should due to the fact i have a young child and transmission of other worms can happen and us not know if are child has worms from the dog. is this a real worrie or are the chances slim and none, i dont like to give unneed meds
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Re: Ivermectin in Heartguard and GSDs
[Re: joseph romano ]
#195160 - 05/16/2008 10:15 AM |
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this is question about heart worm meds, i we to the vet not to long ago and told her i dont give heart worm meds year round, she suggested i should due to the fact i have a young child and transmission of other worms can happen and us not know if are child has worms from the dog. is this a real worrie or are the chances slim and none, i dont like to give unneed meds
Other worms like what?
Heartworm cannot be transmitted from an infected dog to a human.
Mosquitos can transmit heartworm (RARELY) to a human, although humans are not natural hosts for it, but this has nothing at all to do with a dog.
So I would ask, "What worms, exactly?" If you get an answer, I can give you material on how each worm is picked up.
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Re: Ivermectin in Heartguard and GSDs
[Re: Connie Sutherland ]
#195161 - 05/16/2008 10:18 AM |
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Re: Ivermectin in Heartguard and GSDs
[Re: joseph romano ]
#195163 - 05/16/2008 10:25 AM |
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A lot of wormers (non-monthly) kill roundworm.
Roundworm larvae can accumulate in soil where dog fecal matter is allowed to stay.
http://www.petsandparasites.org/dog-owners/roundworms.html
Good hygiene (including hand-washing to wash off any larvae from the dog's coat) is probably the best bet.
But also, dropping off a fecal every so often can reassure you the way nothing else can, and that's my route.
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Re: Ivermectin in Heartguard and GSDs
[Re: Connie Sutherland ]
#195170 - 05/16/2008 11:06 AM |
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I have been giving ivermectin now for 15 yrs to both mals and gsd,s
have never had any problems ,from south fla.
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Re: Ivermectin in Heartguard and GSDs
[Re: Amber Morgan ]
#207055 - 08/24/2008 07:39 AM |
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There certainly can be serious reactions to giving Ivermectin, along with many other common drugs such as Ace, to dogs of the collie and shepherd type breeds. The list of affected dogs has been growing, as has the research by Washington State. I hold the GA shelter license for Mini Aussie Rescue and we are very cautious about this issue. I am treating my GSD with the same caution until I can have him tested.
There is a wealth of information available at http://www.busteralert.org, including how to order the test kits.
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