Connie Sutherland Moderator Reg: 07-13-2005
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Quote: dianeseaman
Connie,
As posted by Andy, Oseltamivir/Tamiflu is a neuraminidase inhibitor. Without getting too technical here, inhibition of neuraminidase activity effectively reduces virulence of the influenza virus, but this is not true for ALL viruses. Some bacteria can also be effectively rendered less virulent in the presence of a neuraminidase inhibitor. Although research is limited, Dr. Broadhurst believes it is the inhibition of BACTERIAL neuraminidase activity rather than any effect on the parvo virus itself that makes Tamiflu useful in canine parvo infection.
If you read Dr. Broadhurst's article posted above, he explains his views on this quite well.
Tamiflu has anti-bacterial activity if the targeted bacteria are affected by inhibition of neuramindase, so in this respect it is an "antibiotic". The same is true for viruses. It has anti-viral activity against viruses that rely on neuraminidase, but would have little direct effect against those that do not.
Yes, I read that: Lessening or surpressing neuramindase can depress the activity and reproduction of some bacteria. At least, that's what I think I got from it. So I guess we are saying that parvo features a virus that is not reliant on neuraminidase, and bacteria that are? (Since we are saying that the virus isn't affected, but the GI bacteria are?)
Connie wrote: "In fact, the whole subject is extremely interesting. If anyone comes up with any connection between G.I. bacteria and virucides, I'd really like the links or titles."
The above link explains the function of neuraminidase in both viruses and bacteria. While parvovirus is not believed to rely on neuraminidase for virulence, it is "believed" (not well-proven) certain GI bacteria become pathogenic in the presence of parvo virus and therefore inhibiting neuraminidase activity of those bacteria reduces symptoms.
Connie Sutherland Moderator Reg: 07-13-2005
Posts: 31571
Loc: North-Central coast of California
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Ah. So if those are the GI bacteria present (case by case), then inhibiting neuraminidase activity can suppress colonization? (My brain is not nimble on this at all ..... but I think I'm following along. Slowly. )
Wow. I had never read/heard any of this, and I REALLY appreciate Andy's post and your answers.
Connie, I think you're understanding it pretty well. I should say as a researcher myself, I still have many unanswered questions and am not fully convinced the theories regarding why Tamiflu might help parvo pups will prove true.
I'll leave you with this thought/question for now: what effect do you think parvovirus infection would have on a puppy with a sterile GI tract (one in which enteric bacteria and parasites had been completely killed off/eliminated before parvo viremia occurred)?
Connie Sutherland Moderator Reg: 07-13-2005
Posts: 31571
Loc: North-Central coast of California
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Quote: DianeSeaman
I'll leave you with this thought/question for now: what effect do you think parvovirus infection would have on a puppy with a sterile GI tract (one in which enteric bacteria and parasites had been completely killed off/eliminated before parvo viremia occurred)?
We have had a lot of parvo puppies and one four year old dog come thru the vet hospital where I work. I think most of them have recieved Tamiflu. One German Shepherd pup was in extremely bad shape but everyone pulled thru.
Lisa
Do you know the vaccination history of the four year old dog with Parvo?
When you say "a lot" can you say how many that is?
How soon did they start on Tamiflu?
What is the latest after on-set of symptoms that any of them started Tamiflu?
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Re: Tamiflu as a Parvo Treatment?
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